The only problem I can see is that of Deadpool's ability to break the Fourth Wall.
It works in comics because you can clearly see the separations, the sound effects, the speech and thought bubbles.
In movies, breaking the Fourth Wall is just addressing the audience.
Unless they think of something totally off the wall, I don't think we're gonna get funny/common sense Deadpool.
Most likely, we're gonna get pithy, toss out one liners, and looks semi badass, Deadpool.