The most stable man in her life (who isn't a warm water penguin) is now her size... you can see Misato fighting herself to try and tease him but what if she drives him off, too?
Haven't played them either, but it's pretty famous...
Example Bioshock logo:
http://vignette4.wikia.nocookie.net/bioshock/images/b/bb/BioShock_2_PC_Multiplayer_Logo.png