As far as Magic goes, I once played Legacy Goblins (R/B) against Charbelcher. To date, it is my only victory against that deck with Goblins.
Game 1: Charbelcher wins the roll and goes ohaiturn1win, kthxbai.
We joke about "Goblin" Charbelcher, making bad puns while we sideboard.
Game 2: I lead with Badlands and a Chalice of the Void for zero. He looks at it blankly. "For...zero?" And then looks at his hand. And then looks at Chalice. "...fuck."
He draws for his turn, drops Bayou, and passes.
I drop a mountain and play Chalice of the Void for 1. He immediately says bad things about my mother and scoops.
Game 3: He does not have the first turn win, and passes without doing anything.
I drop bloodstained mire, fetch badlands, play Thoughtseize. See a hand full of ramp and a charbelcher - all he needed was a 0 cost to start it off. Take charbelcher.
He draws nothing for the rest of the game. Cycles a ton, uses manamorphose and stuff - but just gets nothing. I beat him to death with goblins a few turns
later.
As far as RPGs? Well. I was in a Star Wars campaign recently where we played as Sith soldiers destroying Republic defenses on Coruscant right before the Sith invasion, as seen in the Old Republic trailer.
We manage to be somewhat stealthy when we capture an anti-air defense battery. (Read: I walked in and exclaimed "Holy shit! There are Sith on Coruscant!" and shooting one of the two guards in the face.) So we capture the second one, and its loud enough outside (I started a riot prior to this) and start asking him where the next defensive battery is. He won't talk, and we fail interrogation rolls.
So I went with the expedient of borrowing a vibroblade and cutting off his fingers one at a time. (Really more like 3 at a time, DM ruled I needed to make a DEX roll for accuracy. Failed a bit.)
DM also ruled that, bad rolls or no, the guard wasnt getting paid enough for this, and he fessed up. Then we savagely beat him into unconsciousness.
Then we had a moment where the guy who took Mechanics got to shine - he took both the guard's blasters, set them to overcharge and detonate in about a minute, and went merrily on our way, leaving behind us a sad, sad tale of multiple blaster malfunction. It was a sad tale that would be repeated many a time across that session.